Pre-microRNAs single nucleotide variants (rs3746444 A > G and rs2910164 C > G) increase the risk of ischemic stroke in the Egyptian population: a case–control study

Abstract Background Ischemic stroke (IS) is the most leading cause of morbidity and mortality worldwide. Micro RNA (miRNA) genetic variants have been identified as a part IS non-modifiable risk markers. This study aims to identify possible association rs2910164 C > G pre-miRNA-146a rs3746444 A pre-miRNA-499 with increased risk. C-reactive protein (CRP) was studied one mediators disturbance in IS. The included 100 patients atherosclerotic age sex matched healthy controls more than factor for Variants were evaluated by real-time polymerase chain reaction technique using TaqMan probes. CRP levels assayed immunoturbidimetry method on COBAS analyzer. Results Regarding G, allele, its containing genotypes (GG GG + AG) associated high incidence. Increased found induce AG genotypes, cut value 7.5 mg/ L differentiation between AA genotype genotypes. Combining allele either or had enhanced For combined GC elevation no correlation levels. Conclusion involving an showed higher relation